Genotoxicology Department
Overview
The Genotoxicology Department specializes in evaluating the potential of substances to damage genetic material. These tests are critical for assessing carcinogenicity risk and are mandatory for most regulatory submissions.
Core Capabilities
In Vitro Tests: Ames (bacterial reverse mutation), chromosomal aberration, micronucleus assays.In Vivo Tests: Micronucleus test, Comet assay.Mechanistic Studies: To explore DNA damage pathways. Applications
Agrochemicals (new active substances)Pharmaceuticals (drug candidates, excipients)Industrial chemicals (REACH & global compliance)Medical devices (extractables/leachables) Compliance
OECD Test GuidelinesICH S2 (R1) guidelines 